Premium
Heat stress response and myocardial protection
Author(s) -
Joyeux Marie,
GodinRibuot Diane,
Yellon Derek M.,
Demenge Pierre,
Ribuot Christophe
Publication year - 1999
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1999.tb00314.x
Subject(s) - oxidative stress , heat stress , myocyte , hyperthermia , medicine , cardiology , ischemia , necrosis , ventricular function , mechanism (biology) , pharmacology , biology , zoology , philosophy , epistemology
— Prior whole‐body hyperthermia is able to protect the myocardium against ischaemia‐reperfusion injury by reducing cellular necrosis, preserving the ventricular function and preventing the occurrence of arrhythmias. These cardioprotective effects are associated with reduction of oxidative stress, preservation of the high‐energy phosphate levels and synthesis of heat stress proteins. A better understanding of this powerful protective adaptation of the myocytes would be of interest for potential clinical application, and rational design of specific agents that activate this mechanism will hopefully follow soon.