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RESPIRATION AND BLOOD PRESSURE VARIABILITY: MECHANICAL AND AUTONOMIC INFLUENCES
Author(s) -
Saul J Philip
Publication year - 1998
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1998.tb01027.x
Subject(s) - respiration , respiratory system , blood pressure , heart rate , vagal tone , respiratory rate , cardiology , medicine , hemodynamics , autonomic function , autonomic nervous system , anesthesia , heart rate variability , anatomy
The transfer function between broad‐band respiratory activity and the heart rate (HR) response can be used to elucidate the frequency dependent phase and magnitude characteristics of the respiratory sinus arrhythmia (RSA) 1 . To understand the complex links between respiratory activity and arterial blood pressure (ABP), the transfer functions between instantaneous lung volume (ILV), parameters of arterial pressure, and central venous pressure (CVP) were determined in healthy human volunteers during 6‐minute periods in which the respiratory rate was voluntarily controlled in a predetermined but erratic fashion, or CVP was perturbed with a similar pattern. Pharmacologic autonomic blockade was used to dissect the direct mechanical links between respiration and ABP from the effects of RSA on ABP. The results suggest that with HR fluctuations eliminated, respiration affects ABP in proportion to the rate of change of ILV; however, when neural control of HR remains intact, the RSA plays an important role in the genesis of ABP fluctuations.