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Endogenous central cholinergic systems and baroreflex modulation in the conscious dog
Author(s) -
Lazartigues E,
Tran MA,
BrefelCourbon C,
Montastruc JL,
Rascol O
Publication year - 1998
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1998.tb00999.x
Subject(s) - baroreflex , endogeny , cholinergic , neuroscience , cholinergic system , medicine , endocrinology , biology , blood pressure , heart rate
Summary— Intracisternal atropine and mecamylamine failed to modify baroreflex sensitivity in dogs, suggesting a lack of cholinergic neurons integrated in baroreflex pathways. Conversely, neostigmine lowered baroreflex sensitivity suggesting a putative cholinergic modulation.