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Effects of α 1 ‐acid glycoprotein in different rodent models of shock
Author(s) -
Muchitsch EM,
Auer W,
Pichler L
Publication year - 1998
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1998.tb00938.x
Subject(s) - shock (circulatory) , mean arterial pressure , albumin , septic shock , medicine , resuscitation , lipopolysaccharide , glycoprotein , perfusion , anesthesia , lactic acid , placebo , blood pressure , pharmacology , sepsis , chemistry , heart rate , biochemistry , biology , pathology , bacteria , genetics , alternative medicine
Summary— It was the aim of the present study to investigate the effects of the acute phase protein α 1 ‐acid glycoprotein in different models of shock. The human plasma preparation used was without effect on mortality in lipopolysaccharide‐injected mice when administered in two different doses (1 or 0.33 g/kg iv) and according to different treatment schedules. The same preparation significantly increased survival rate (48 h) in rats with septic peritonitis. This effect was seen when α 1 ‐acid glycoprotein (200 mg/kg iv) was given 15 min prior to and 24 h after cecal puncture. All other dose regimes tested were without significant effect on survival rate. A hemorrhagic/hypovolemic shock model (including a defined trauma) in rats resuscitated with 200 mg/kg α 1 ‐acid glycoprotein resulted in significantly higher values of mean arterial blood pressure, cardiac output and stroke volume when compared to corresponding values obtained after resuscitation with Ringer's solution or 200 mg/kg albumin iv (free of α 1 ‐acid glycoprotein; placebo formulation). Taking all other possible mechanisms of α 1 ‐acid glycoprotein into consideration, the partially protective effects of the preparation are explained by enhancing the capillary barrier function and thereby maintaining perfusion of vital organs.