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Studies on the possible mechanism of the gastric mucosal protection by Calotropis procera — involvement of 5‐lipoxygenase pathway
Author(s) -
Sen T,
Basu A,
Chaudhuri AK Nag
Publication year - 1998
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1998.tb00928.x
Subject(s) - calotropis procera , lipoxygenase , chemistry , aspirin , arachidonic acid , ethanol , pharmacology , ulcer index , chloroform , gastric mucosa , biochemistry , enzyme , traditional medicine , stomach , medicine , chromatography
Summary— The role of chloroform fraction of Calotropis procera root extract on different experimental ulcer models in rats was investigated. The extract demonstrated significant anti‐ulcer activity against aspirin, indomethacin, ethanol, indomethacin + ethanol, or stress‐induced ulcerations. Significant inhibition of gastric secretory volume and total acidity in pylorus ligated rats were observed to occur with the extract. It was also observed that the root extract significantly inhibited arachidonic acid metabolism induced by soyabeian lipoxygenase. The results suggest that the anti‐ulcer activity of the extract might be attributable to the inhibition of 5‐lipoxygenase (5‐LO).