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Effects of carbamazepine on plasma extravasation and bronchoconstriction induced by substance P, capsaicin, acetaldehyde and histamine in guinea‐pig lower airways
Author(s) -
Bianchi M,
Rossoni G,
Maggi R,
Panerai AE,
Berti F
Publication year - 1998
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1998.tb00924.x
Subject(s) - bronchoconstriction , extravasation , capsaicin , histamine , pharmacology , chemistry , guinea pig , evans blue , substance p , carbamazepine , in vivo , anesthesia , endocrinology , receptor , medicine , biochemistry , immunology , biology , neuropeptide , airway , epilepsy , microbiology and biotechnology , psychiatry
Summary— We evaluated the in vivo effects of the pretreatment with carbamazepine (CBZ) at different doses (10, 20 and 40 mg/kg p.o.) on the Evans‐blue extravasation and on bronchoconstriction induced by different substances in guinea‐pig tracheal tissue. The drug dose‐dependently inhibited the extravasation induced by substance P (SP), capsaicin and acetaldehyde, but not that induced by histamine. At the highest dose (40 mg/kg) CBZ inhibited the bronchoconstriction induced by SP, capsaicin and acetaldehyde, but not that produced by histamine administration. The in vitro study with guinea‐pig tracheal preparation indicates that the drug does not interfere with the binding of SP to its receptors. Our results suggest that CBZ exerts a protective activity against the pro‐inflammatory action of SP.