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Enhancement of the vasodepressor response to adenosine by nicorandil in rats: comparison with cromakalim
Author(s) -
Saito K,
Sakai K
Publication year - 1998
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1998.tb00921.x
Subject(s) - nicorandil , cromakalim , adenosine , glibenclamide , medicine , chemistry , potassium channel opener , endocrinology , potassium channel , pharmacology , anesthesia , diabetes mellitus
Summary— The effect of nicorandil on systemic blood pressure (SBP) and heart rate (HR) responses to adenosine was compared with that of cromakalim, an adenosine triphosphate (ATP)‐sensitive K + channel opener, in anesthetized rats. Intravenous (iv) adenosine in doses of 1–100 μg/kg elicited dose‐dependent decreases in SBP, accompanied by decreases in HR. Potentiation of adenosine action by iv infusion of either nicorandil (10 or 30g/kg per min) or cromakalim (0.1 μg/kg per min) occurred in all of the animals tested. After iv treatment with glibenclamide (20 mg/kg), an ATP‐sensitive K + channel blocker, not only adenosine action but also the enhancement of adenosine action by nicorandil and cromakalim were significantly attenuated. The present result indicates that the enhancement of the adenosine action by nicorandil and cromakalim appears to occur at least partly through ATP‐sensitive K + channel activation.