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Experimental study of antidiarrheal activity of Salicairine®
Author(s) -
Brun Y,
Wang XP,
Willemot J,
Sevenet T,
Demenge P
Publication year - 1998
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1998.tb00920.x
Subject(s) - loperamide , chemistry , absorption (acoustics) , medicine , duodenum , endocrinology , diarrhea , physics , acoustics
Summary— Experimental antidiarrheal activity of a traditionally used medication, Salicairine®, was demonstrated in comparison to loperamide by significant inhibition of castor oil‐induced diarrhea in mice (increases in hard faeces/total faeces ratio of 38 and 54 and 5 and 54% with respect to controls, at 0.5 and 1 mL/kg and 1 and 2 mg/kg, respectively) and bisacodyl‐induced increase in large intestine transit in rats (125 and 280 and 210% with respect to controls, at 0.4 and 2 mL/kg Salicairine® and 5 mg/kg loperamide, respectively). Salicairine® was able to reduce contractions of isolated rat duodenum induced by barium chloride and acetylcholine, although not completely (that is about 60%) as seen with loperamide. Also, it did not change normal gastrointestinal transit in mice at doses of 0.5 to 1 mL/kg, conversely to loperamide which had a significant effect (decrease of 50%) at 2 mg/kg. Finally, Salicairine® at 0.01 mL/mL, like loperamide at 0.2 mg/mL, significantly increased net fluid absorption in rat colon, either in basal conditions (30 and 64% respectively) or after a prostaglandin E 1 ‐induced increase in net fluid secretion (41 and 35%, respectively). The antidiarrheal activity of Salicairine® is possibly related, at least in part, to an increase in colon net fluid absorption or a decrease in net fluid secretion.