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Effects of pretreatment with clonidine, lithium and quinine on the activities of antidepressant drugs in the mouse tail suspension test
Author(s) -
Redrobe JP,
Bourin M.
Publication year - 1997
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1997.tb00199.x
Subject(s) - ritanserin , pharmacology , clonidine , mianserin , chemistry , imipramine , lithium (medication) , agonist , serotonergic , tail suspension test , antagonist , antidepressant , receptor antagonist , endocrinology , serotonin , behavioural despair test , medicine , receptor , biochemistry , alternative medicine , pathology , hippocampus
Summary— The aim of the present study was the investigation of pretreatment effects with clonidine (0.06 mg/kg, intraperitoneal [ip]), lithium (1 mEq, ip) or quinine (0.5 mg/kg, ip) on the activities of various drugs acting on noradrenergic and/or serotonergic systems in the mouse tail suspension test. Drugs used in the present study included: the tricyclic antidepressants imipramine and dothiepin, the heterocyclic antidepressant trazodone, the 5‐HT reuptake inhibitor (SSRI) fluoxetine, the atypical antidepressants mianserin and iprindole, the 5‐HT 1A receptor agonist ipsapirone, the 5‐HT 2A/2C receptor antagonist ritanserin, and the 5‐HT 3 receptor antagonist ondansetron. Clonidine, lithium and quinine differentially enhanced the effects of several psychotropic drugs administered at sub‐active doses. The activity of iprindole (32 mg/kg, ip) was not potentiated by pretreatment with clonidine, lithium or quinine. Our results suggest that lithium exerted additive effects via postsynaptic 5‐HT 1A receptor activation, quinine via potassium ion channel blockade of 5‐HT 3 receptors, while clonidine did so primarily via action at 5‐HT 2 receptors.