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Response of large and small vessels to α and β adrenoceptor stimulation in heart failure: effect of angiotensin converting enzyme inhibition
Author(s) -
Mulder P.,
Compag P.,
Devaux B.,
Richard V.,
Henry JP,
Elfertak L.,
Wimart MC,
Thibout E.,
Comoy E.,
Macé B.,
Thuillez C.
Publication year - 1997
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1997.tb00189.x
Subject(s) - medicine , phenylephrine , vasodilation , endocrinology , heart failure , angiotensin ii , mesenteric arteries , aorta , lisinopril , vasoconstriction , ace inhibitor , angiotensin converting enzyme , prazosin , artery , antagonist , blood pressure , receptor
Summary— The increased sympathetic drive in chronic heart failure (CHF) might provoke vascular adrenoceptor desensitization, which, together with endothelial dysfunction, could contribute to the altered vasomotor tone seen in CHF. We investigated 1) whether CHF alters the responses mediated by α and β adrenoceptors in small and large peripheral arteries, and 2) the effect of angiotensin‐converting enzyme (ACE) inhibition. Rats with CHF (coronary artery ligation) were treated with placebo or the ACE inhibitor lisino‐pril (10 mg/kg/d) starting 7 days after ligation. Responses to phenylephrine (α, agonist), salbutamol (β 2 agonist) as well as acetylcholine (endothelium‐dependent), were assessed after 3 months in isolated and pressurized segments of the abdominal aorta, the femoral and the mesenteric arteries. In animals with hemodynamic signs of CHF, neither the vasoconstrictor responses to phenylephrine nor the vasodilator response to salbutamol were affected. In contrast, the dilator response to acetylcholine of both small arteries, but not that of the aorta, was impaired. Furthermore, CHF did not modify vessel structure. While lisinopril did not modify the responses to adrenergic agonists, it normalized the response to acetylcholine. Furthermore, ACE inhibition reduced vascular media cross sectional area and collagen density. Thus, the unchanged arterial responsiveness to adrenoceptor agonists does not indicate any vascular adrenoceptor desensitization, while endothelial dependent vasodilation of small arteries is impaired in CHF. ACE inhibition does not modify the response to adrenergic stimuli, prevents endothelial dysfunction and induces both cardiac and vascular remodeling, which probably contribute to the effect ACE inhibitors have on exercise tolerance and survival.