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Modulation by alcohol and methadone of 2‐deoxyglucose‐stimulated pancreatic secretion in the rat
Author(s) -
NagainDomaine C.,
Tsocas A.,
Presset O.,
Rozé C.,
Vaille C.
Publication year - 1996
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1996.tb00612.x
Subject(s) - endocrinology , deoxyglucose , medicine , ethanol , methadone , secretion , inhibitory postsynaptic potential , alcohol , receptor , chemistry , pharmacology , biochemistry
Summary— Alcohol intake is a major problem in drug addicts, and it is not clear whether the effects of alcohol and opiates are additive or potentiating. Vagally stimulated pancreatic secretion in rats is potently inhibited by opiates acting centrally at μ‐receptors. In the present experiments, we determined the effects of methadone on 2‐deoxyglucose (2DG)‐stimulated pancreatic secretion in rats treated with acute (1.9 g/kgṁ3 h, intravenously) or chronic (1 or 3 month drinking) ethanol. In both acute and 1 month chronic alcoholic rats, methadone administered at its 50% inhibitory dose (ID50) reduced by about 50% 2DG‐stimulated pancreatic secretion of sodium, bicarbonate and protein, and ethanol had only faint, nonsignificant inhibitory effects. In 3 month chronic alcoholic rats, similar results were obtained, but methadone inhibited 2DG‐stimulated pancreatic secretion by 60 to 90% in these older rats. No significant interaction was found in any condition between ethanol and methadone, suggesting that they had only additive, but not potentiating effects in this model.