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The effect of cyclosporine A and trifluoperazine on amylase secretion from rat parotid glands in vitro
Author(s) -
Samini M.,
Dehpour AR,
Ghafourifar P.,
Hassanzadeh P.
Publication year - 1995
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1995.tb00531.x
Subject(s) - trifluoperazine , calmodulin , secretion , amylase , endocrinology , medicine , antagonist , parotid gland , in vitro , biology , chemistry , enzyme , calcium , biochemistry , receptor , pathology
Summary— In the present study the effects of trifluoperazine (TFP) and/or cyclosporine A (CsA) on the amylase secretion of rat parotid gland lobules were investigated. Cyclosporine A, in doses of 10 −6 , 3 × 10 −6 and 10 −5 M, caused a dose‐dependent reduction in amylase secretion. Trifluoperazine, a well‐established calmodulin antagonist, also significantly reduced amylase secretion by the gland, confirming that the secretion is calmodulin dependent. Concurrent administration of CsA and TFP showed a marked positive interaction in reducing the secretion of amylase. Thus, the hypothesis that CsA may have Ca 2+ /calmodulin antagonistic properties is supported by the present study.