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Restoration of brain protein synthesis in mature and aged rats by a DA agonist, piribedil
Author(s) -
Bustany P.,
Trenque T.,
Crambes O.,
Moulin M.
Publication year - 1995
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1995.tb00521.x
Subject(s) - dopaminergic , agonist , ageing , dopamine , medicine , endocrinology , psychology , receptor
Summary— Brain ageing affects numerous cerebral metabolic pathways such as cerebral glucose consumption or protein synthesis rate. The pharmacological effect of a mixed D 1 ‐D 2 dopaminergic agonist, piribedil, on this last metabolism is reported. Cerebral Protein Synthesis Rate (CPSR) was measured by the [ 35 S]L‐methionine autoradiographic procedure in 38 main brain regions of 11 and 26‐month‐old Wistar rats after a 2‐month treatment per os at 9 and 30 mg/kg/day with piribedil. Mean decrease of CPSR was −21% during the 15‐month ageing we followed, with important local variations. Mean CPSR increased with the two treatments, +25% in mature and +35% in aged rats. Treatments restored CPSR of aged rats to the exact mature subjects levels in quite all the brain regions. No dose‐effect or asymetrical modification was statistically revealed for the two treatments. Metabolic increases involved particularly central brain gray structures, especially some DA‐targeted brain nuclei concerned with behaviour and learning. This effect argued for a general metabotrophic effect of D 1 ‐D 2 dopamine stimulation of the brain. The original pattern of local ageing of brain protein synthesis in rat was also incidentally reported. This was the first direct report of a wide and effective metabolic activation of CPSR in the brain during ageing by a curative dopaminergic agonist treatment.