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Beta 3 ‐adrenoceptors and airways *
Author(s) -
Martin CAE,
Advenier C.
Publication year - 1995
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1995.tb00270.x
Subject(s) - endocrinology , stimulation , medicine , beta (programming language) , propranolol , beta 3 adrenergic receptor , skeletal muscle , guinea pig , adrenergic receptor , epithelium , biology , muscle contraction , respiratory tract , chemistry , respiratory system , receptor , pathology , computer science , programming language
Summary— β 3 ‐adrenoceptors have been identified in a variety of tissues from humans and animals: adipose tissue, gastrointestinal smooth muscle, rat skeletal muscle, bovine skeletal muscle, and human and canine heart. In the airways, the investigation of the β 3 ‐adrenoceptors came from studies with a series of novel selective agonists. Stimulation of the “atypical” β‐adrenoceptor increases the active transport of albumin across the ferret tracheal epithelium and the ciliary beat frequency of canine bronchial epithelium. Furthermore, it has been demonstrated that β 3 ‐adrenoceptors agonists selectively inhibited nonadrenergic noncholinergic contractions of guinea‐pig bronchi induced by electrical field stimulation or capsaicin. The presence of functional β 3 ‐adrenoceptors in the bronchial smooth muscle is disputed and seems to be species‐related. In isolated canine bronchi, selective agonists induced a relaxation whereas they had no or slight effect in isolated human, guinea‐pig and sheep bronchi. Likewise in man, a fall in airway resistance measured by plethysmography, was mediated by β 2 ‐adrenoceptors, but not β 3 ‐adrenoceptors. To conclude, an “atypical” or β 3 ‐adrenoceptor‐mediated modulation of bronchomotricity exists, nevertheless strong species specific differences have been reported.