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Influence of food and body weight on the pharmacokinetics of penticainide
Author(s) -
Berdaï D.,
DemotesMainard F.,
Philip F.,
Vinçon G.,
Montels R.,
Necciari J.,
Bannwarth B.
Publication year - 1994
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1994.tb00825.x
Subject(s) - pharmacokinetics , meal , body weight , urine , zoology , oral administration , plasma concentration , chemistry , high performance liquid chromatography , endocrinology , medicine , biology , chromatography
Summary— The pharmacokinetics of penticainide, a class Ic antiarrhythmic drug, was studied in 16 healthy adults (eight males and eight females) after a single 300‐mg oral dose in fasting conditions and with a standard meal. Penticainide concentrations in plasma and urine were measured by hplc. The pharmacokinetic parameters of penticainide including C max , t max , AUC and t 1/2 were not significantly altered in the presence of food. AUC values (mean ± sd) were 50.68 ± 10.8 mg·h·l −1 and 49.52 ± 9.87 mg·h·l −1 in the absence and presence of food, respectively. However, a significant difference was observed between males and females in both fasting and fed conditions with a higher value of the apparent oral clearance in the second group. The values of apparent oral clearance, expressed in weight‐normalized units were 1.33 ± 0.35 ml·mn −1 ·kg −1 (male) and 1.93 ± 0.34 ml·mn −1 ·kg −1 (female) in fast conditions ( P < 0.01) and 1.38 ± 0.28 ml·mn −1 ·kg −1 (male) and 1.93 ± 0.49 ml·mn −1 ·kg −1 (female) in fed conditions ( P < 0.02), respectively. The pharmacokinetics of penticainide is not modified by the presence of food, but an influence of body weight may be considered.