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Comparative study of erythromycin, troleandomycin and tylosin on the rabbit intestine
Author(s) -
Kounenis G.,
KoutsovitiPapadopoulou M.,
Elezoglou V.
Publication year - 1994
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1994.tb00794.x
Subject(s) - tylosin , erythromycin , ileum , potency , biology , oleandomycin , jejunum , antibiotics , macrolide antibiotics , ascending colon , circular muscle , antibacterial agent , microbiology and biotechnology , medicine , endocrinology , in vitro , biochemistry , smooth muscle
Summary— The macrolide antimicrobial agents, erythromycin, troleandomycin and tylosin were tested for their effect on isolated whole segments of the rabbit duodenum, jejunum, ileum and ascending colon, as well as on strips of the circular and longitudinal smooth muscle of the ascending colon. The 14‐membered macrolides erythromycin and troleandomycin were found to possess a concentration‐dependent contractile effect on the intestinal smooth muscle. The order of potency was: erythromycin > troleandomycin. The 16‐membered macrolide tylosin was found to have a much weaker potency than erythromycin and troleandomycin. In addition, the circular smooth muscle of the ascending colon was found to be more sensitive to the compounds tested than the longitudinal smooth muscle.