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Indapamide inhibits endothelium‐dependent contractions in the aorta of the spontaneously hypertensive rat
Author(s) -
Boulanger CM,
Mombouli JV,
Vanhoutte PM
Publication year - 1993
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1993.tb01040.x
Subject(s) - indapamide , endothelium , acetylcholine , medicine , vasodilation , endocrinology , aorta , adenosine , vascular smooth muscle , chemistry , nitric oxide , contraction (grammar) , endothelium derived relaxing factor , pharmacology , smooth muscle , blood pressure
Summary— Experiments were designed to determine whether or not indapamide, an antihypertensive agent with vasodilator properties, inhibits endothelium‐dependent contractions. Rings of aortae with and without endothelium from spontaneously hypertensive rats (SHR) were suspended in conventional organ chambers for the measurement of isometric force. Acetylcholine and adenosine diphosphate‐β‐S in the presence of a nitric oxide synthase inhibitor, caused endothelium‐dependent contractions, which were inhibited by indapamide. The compound (10 −4 M) also slightly reduced the contractions of rings without endothelium evoked by U‐46,619, which activates thromboxane‐endoperoxide receptors. These results demonstrate that indapamide inhibits endothelium‐dependent contractions in the SHR aorta, and suggest that the inhibition is due, at least in part, to the action of the drug on the hypertensive vascular smooth muscle.