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Fever‐induced changes in theophylline pharmacokinetics in rats
Author(s) -
Bruguerolle B.,
Dubus JC
Publication year - 1993
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1993.tb01038.x
Subject(s) - theophylline , pharmacokinetics , saline , albumin , chemistry , pharmacology , volume of distribution , medicine
Summary— Our aim was to document possible alterations of theophylline pharmacokinetics in rats during fever. Two groups (group A = normothermic controls, group B = fever‐induced animals) of Wistar AF IOPS male rats were injected at 19 30 h either with 2 g/kg of brewer's yeast subcutaneously (20% w/v) or with the equivalent volume of saline. Twelve hours later at 07 30 h the two groups received a single 12 mg/kg/IP dose of theophylline. Blood samples were obtained by retro‐orbital sinus puncture 0, 0.25, 0.5, 1, 2, 4, 8, 12, 16 and 24 hours after administration. A third group of 10 male IOPS rats (group C) were used under the same experimental conditions in order to determine the influence of brewer's yeast‐induced fever on biological parameters. C max , T max , C max /T max , T 1/2, Cl, Vd and AUC were determined according to a one‐compartment open model. Our results confirm the fever‐induced decrease in total plasma proteins and albumin but do not demonstrate any significant change in theophylline pharmacokinetic parameters.