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Rolipram inhibits PAF‐induced airway microvascular leakage in guinea‐pig: a comparison with milrinone and theophylline
Author(s) -
Ortiz JL,
Cortijo J.,
Vallés JM,
Bou J.,
Morcillo EJ
Publication year - 1992
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1992.tb00117.x
Subject(s) - rolipram , milrinone , theophylline , phosphodiesterase , pharmacology , phosphodiesterase inhibitor , chemistry , guinea pig , anesthesia , medicine , endocrinology , enzyme , biochemistry , hemodynamics
Summary— The effects of 3 phosphodiesterase (PDE) inhibitors, rolipram (PDE IV), milrinone (PDE III) and theophylline (nonselective) on PAF (50 ng kg −1 ; iv)‐induced airway vascular leakage have been evaluated in guinea‐pigs. Rolipram (3–300 μg kg −1 ; iv) reduced the increase in permeability induced by PAF at all airway levels whereas milrinone (10–1000 μg kg −1 ; iv) and theophylline (30 mg kg −1 ; iv) were without effects. The anti‐leakage activity of rolipram may be of therapeutic value in asthma.