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The comparison of the effects of multi and single doses of buspirone, chlordiazepoxide and hydroxyzine on psychomotor function and EEG
Author(s) -
Blom MW,
Bartel PR,
Sommers DK,
Meyden CH,
Becker PJ
Publication year - 1992
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1992.tb00087.x
Subject(s) - hydroxyzine , buspirone , psychomotor learning , chlordiazepoxide , anesthesia , flicker fusion threshold , placebo , medicine , psychology , audiology , electroencephalography , saccadic masking , diazepam , eye movement , neuroscience , cognition , psychiatry , flicker , serotonin , receptor , alternative medicine , pathology , electrical engineering , engineering
Summary— This study compares the effects of buspirone (5 mg), chlordiazepoxide (5 mg), hydroxyzine (10 mg) and placebo on psychomotor function and EEG, when taken thrice daily for a period of two weeks, with those after a single dose administration. Nine healthy volunteers participated in the study. The battery of psychomotor tests included peak velocity of saccadic eye movements (SEM), a Sternberg memory scanning and choice reaction time test (SMS‐CRT) and critical flicker fusion frequency (CFFF). The peak velocity of saccadic eye movements was significantly impaired by the single dose of hydroxyzine ( P = 0.03) in comparison to the multidose results. A similar comparison regarding buspirone only approached significance ( P = 0.07). The SMS‐CRT and CFFF did not reveal any difference between the multi and single dose regimens. Spectral analysis of the EEG did not distinguish between the multi and single dosage schedules regarding the respective drugs in the low doses administered.