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Effects of cicletanine on vasoactive systems in conscious sinoaortic‐denervated dogs
Author(s) -
DamaseMichel C.,
Girolami JP,
Bascands JL,
Tran MA,
Moatti JP,
Pecher C.,
Berthet P.,
Tarrade T.,
Montastruc JL
Publication year - 1991
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1991.tb00760.x
Subject(s) - plasma renin activity , medicine , endocrinology , aldosterone , baroreceptor , blood pressure , diuretic , heart rate , renin–angiotensin system , stimulation , pharmacology , chemistry
Summary— The present study investigates the antihypertensive action of cicletanine, a new antihypertensive compound with diuretic properties (or placebo), on vasopressor (catecholamines, renin‐aldosterone) as well as vasodepressor (prostaglandins, kallikrein‐kinin) systems in conscious chronic sinoaortic denervated (SAD) dogs. Cicletanine (10 mg/kg twice a day, per os, for one month) lowered blood pressure and heart rate. The antihypertensive action does not involve an effect on sympathetic tone (since plasma catecholamine levels were unmodified) or on plasma aldosterone levels. By contrast, urinary 6 keto PGF 1 or PGE 2 levels and kallikrein activity were enhanced. This result indicates that the antihypertensive effect of cicletanine is associated with a stimulation of potential vasodepressor systems (such as prostaglandins or kinins).