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Pharmacokinetics of methohexital during cardiovascular surgery with cardiopulmonary bypass
Author(s) -
Foussadier A.,
Boulieu R.,
Lehot JJ,
Ferry S.
Publication year - 1991
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1991.tb00748.x
Subject(s) - cardiopulmonary bypass , pharmacokinetics , medicine , methohexital , anesthesia , volume of distribution , cardiac surgery , intravenous bolus , bolus (digestion) , hypothermia , surgery , propofol
Summary— The pharmacokinetics of methohexital after intravenous bolus administration was studied during cardiovascular surgery with cardiopulmonary bypass. The effect of body temperature (normother‐mia and hypothermia) during cardiopulmonary bypass on methohexital pharmacokinetics was investigated. The pharmacokinetic data obtained were compared with those from vascular surgery without cardiopulmonary bypass. A marked decrease in plasma methohexital concentrations and therefore in area under curve and a significant increase in clearance and in volume of distribution were observed in the cardiopulmonary bypass groups compared to the vascular surgery group without cardiopulmonary bypass. However, the elimination half‐life and the mean residence time were similar in the 2 groups. Furthermore, the study shows that body temperature during cardiopulmonary bypass does not influence methohexital pharmacokinetics.