Premium
Effects of troleandomycin and josamycin on thyroid hormone and steroid serum levels, liver function tests and microsomal monooxygenases in healthy volunteers: a double blind placebo‐controlled study
Author(s) -
Uzzan B.,
Nicolas P.,
Perret G.,
Vassy R.,
Tod M.,
Petitjean O.
Publication year - 1991
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1991.tb00738.x
Subject(s) - endocrinology , medicine , josamycin , placebo , excretion , analysis of variance , monooxygenase , cytochrome p450 , metabolism , alternative medicine , clarithromycin , pathology , helicobacter pylori
Summary— Serum TSH levels are moderately but significantly ( P ANOVA: 0.05) decreased by troleandomycin (T; 1 g bid over a 10‐day period) compared with josamycin (J) (same doses) and placebo (P) in healthy volunteers. T also significantly increases serum estradiol concentration ( P ANOVA: 0.03). This effect may be related to a T‐induced inhibition of some P450 monooxygenase isoenzymes and more specifically P 450 NF, determined in our study by a decrease in urinary excretion of 6‐β‐hydroxy‐cortisol. Troleandomycin and josamycin both show poor upper GI tolerance. Liver enzymes (SGOT, SGPT, alkaline phosphatase and gGT) are significantly altered by T compared with J and P ( P ANOVA: 0.007, 0.001, 0.09 and 0.04 respectively). After J, liver function tests are very close to control values (placebo). Liver enzymes are significantly more altered by T than by J ( P 0.004, 0.001 and 0.06 for SGOT, SGPT and gGT respectively). Using 6 volunteers in a latin‐square designed study, some established effects of oral macrolides were confirmed (poor upper GI tolerance; liver toxicity of T). Some other effects of T were also elicited, which were either unknown (decrease in serum TSH) or expected but which had not previously been assessed in man (increase in serum estradiol; decreased urinary excretion of 6‐β‐hydroxy‐cortisol).