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Amiodarone: influence of the route of administration on thyroid status and cardiac β‐adrenoceptors in the rat
Author(s) -
Yin YL,
Nicolas P.,
Vassy R.,
Uzzan B.,
Pussard E.,
Berdeaux A.,
Perret G.
Publication year - 1991
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1991.tb00735.x
Subject(s) - medicine , endocrinology , amiodarone , thyroid , hormone , oral administration , thyroid hormones , chemistry , receptor , atrial fibrillation
Summary— The influence of 2 different routes of amiodarone (AMIO) administration, oral gavage (OG) and subcutaneous injection (SC), on the density of cardiac β‐adrenoceptors ( B max ), hepatic type I 5′ iodothyronine deiodinase (5′ DI) and thyroid hormone serum concentrations was studied. Compared with respective control values, AMIO treatment (50 mg/kg per day, 7 days) via both OG and SC routes significantly lowered B max (OG: 14.6 ± 1.92 vs 18.2 ± 1.03 fmol/mg and SC: 16.6 ± 2.34 vs 19.1 ± 2.05 fmol/mg) and 5′ DI activity (from 409 to 85 and 340 to 47 fmol I − /mg per min, respectively). The SC route induced a fall in thyroid secretion and a generalized hypothyroidism (decreased serum FT4 and FT3, inhibition of body weight gain. The OG route did not modify thyroid secretion. These results demonstrated that the effects on cardiac β‐receptor density in the SC group might be due to the generalized hypothyroidism and that AMIO produced its specific cardiac effects only after oral route medication, suggesting that the oral route is the best choice for studying AMIO cardiac effects on β‐receptor density.