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Effects of administration route on valproate pharmacokinetics in the rabbit
Author(s) -
Bourin M.,
Guenzet J.,
Thomare P.,
Kergueris MF,
Ortega A.,
Larousse C.
Publication year - 1991
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1991.tb00727.x
Subject(s) - pharmacokinetics , bioavailability , cmax , volume of distribution , absorption (acoustics) , pharmacology , valproic acid , chemistry , oral administration , distribution (mathematics) , gastrointestinal tract , plasma concentration , medicine , biochemistry , epilepsy , mathematical analysis , physics , mathematics , psychiatry , acoustics
Summary— The absorption of sodium valproate was studied in 5 rabbits: Each animal received the drug (70 mg/kg) via 3 routes: intravenous, gastric and duodenal. For the 2 extravascular routes, the absolute bioavailability F , maximal plasma concentrations C max , times to peak T max and absorption coefficients K abs were the same. Absolute bioavailability was always close to unity. This indicated that valproic acid was absorbed from the intestine as well as from the whole gastrointestinal tract. The other pharmacokinetic parameters such as terminal plasma half‐life, total clearance and volume of distribution remained unchanged whatever the route of administration.