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Positron emission tomography studies of brain receptors
Author(s) -
Mazière B.,
Mazière M.
Publication year - 1991
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1991.tb00702.x
Subject(s) - positron emission tomography , human brain , in vivo , neuroscience , brain positron emission tomography , preclinical imaging , binding potential , receptor , nuclear medicine , chemistry , medicine , psychology , biology , microbiology and biotechnology
Summary— Probing the regional distribution and affinity of receptors in the brain, in vivo , in human and non human primates has become possible with the use of selective ligands labelled with positron emitting radionuclides and positron emission tomography (PET). After describing the techniques used in positron emission tomography to characterize a ligand receptor binding and discussing the choice of the label and the limitations and complexities of the in vivo approach, the results obtained in the PET studies of various neurotransmission systems: dopaminergic, opiate, benzodiazepine, serotonin and cholinergic systems are reviewed.