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Electrotherapy in mice: dopaminergic and noradrenergic effects in the Tail Suspension Test
Author(s) -
Teste JF,
Martin I,
Rinjard P
Publication year - 1990
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1990.tb01015.x
Subject(s) - sulpiride , yohimbine , dopaminergic , nomifensine , tail suspension test , electrotherapy , methysergide , medicine , propranolol , antidepressant , bupropion , metergoline , nifedipine , anesthesia , endocrinology , antagonist , behavioural despair test , serotonergic , dopamine , serotonin , receptor , alternative medicine , pathology , hippocampus , smoking cessation , calcium
Summary— The Tail Suspension Test (TST) is a psychotropic screening test which is used principally to detect antidepressant activity. Electrotherapy (ECT) is used to treat depressions which are resistant to the usual antidepressant drugs and has proved to have a profile in the TST approaching that of antidepressants after treating mice at the rate of 2 shocks per day for 5 days. The results of a single treatment were not statistically different from those of the control group, whereas single daily treatment for 5 days showed a reduction in immobility which did not differ significantly from the control group. The reduction in immobility, induced by 5 days of ECT treatment twice daily, was antagonized by sulpiride and prazosine but not by yohimbine, methysergide, metergoline and DL propranolol. The results suggest that electrotherapy leads to an increase in noradrenergenic and dopaminergic activities expressed by a reduction in immobility in the TST.