Premium
Inhibition by chlordiazepoxide of adenosine‐stimulated glucagon secretion
Author(s) -
Chapal J.,
Roye M.,
Petit P.,
LoubatièresMariani MM
Publication year - 1990
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1990.tb00488.x
Subject(s) - adenosine , glucagon , endocrinology , medicine , chlordiazepoxide , chemistry , secretion , pharmacology , biology , hormone , diazepam
Summary— The action of a water soluble benzodiazepine, chlordiazepoxide (CDZ) on the stimulatory effect of adenosine on glucagon secretion from the isolated pancreas of the rat perfused in presence of 2.8 mM glucose was studied. CDZ 10 −7 and 10 −6 M had no effect per se on glucagon secretion under our experimental conditions. In contrast, CDZ 10 −6 M (but not 10 −7 M) markedly reduced the peak of glucagon secretion provoked by adenosine, 2‐chloroadenosine (1.65 times 10 −6 M) and by a stable analogue, 5′‐ N ‐ethylcarboxamidoadenosine or NECA (1.65 times 10 −8 M). This peripheral interaction between CDZ and adenosine seemed to be specific, since CDZ did not modify the peak of glucagon secretion induced by (‐)isoproterenol (10 −8 M). Our results demonstrate an inhibitory effect of CDZ on adenosine‐stimulated glucagon secretion.