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The place of simultaneous pharmacokinetic pharmacodynamic modeling in new drug development: trends and perspectives *
Author(s) -
Girard P.,
y P.,
Boissel JP
Publication year - 1990
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1990.tb00068.x
Subject(s) - pharmacodynamics , drug development , pharmacokinetics , pharmacology , drug , medicine
Summary— The potential applications in drug development of pharmacokinetic‐pharmacodynamic modeling are numerous: optimal medication regimen, design of galenic forms, identification of specific effects of metabolites and enantiomers. Nevertheless, this methodology is presently under‐used, as appears from an analysis of the literature. We examine this point as well as progress in both non‐invasive pharmacodynamic measurement and specific experimental design that could lead to a future extension of PK‐PD in toxicology and phase I drug development.