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NORADRENALINE RELEASE IN HUMAN CORPUS CAVERNOSUM AND ITS MODULATION VIA PRESYNAPTIC α 2 ‐ADRENOCEPTORS
Author(s) -
MOLDERINGS G.J.,
GÖTHERT M.,
AHLEN H.,
PORST H.
Publication year - 1989
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1989.tb00684.x
Subject(s) - rauwolscine , methoxamine , agonist , endocrinology , medicine , desipramine , tetrodotoxin , chemistry , stimulation , antagonist , receptor , yohimbine , biology , antidepressant , hippocampus
Summary— Strips of human corpus cavernosum were incubated with 3 H‐noradrenaline and subsequently superfused with physiological salt solution containing desipramine and corticosterone. The electrically (0.66 Hz) evoked tritium overflow was abolished by tetrodotoxin or omission of Ca 2+ from the superfusion fluid. The α 2 ‐adrenoceptor agonist B‐HT 920 (6‐allyl‐2‐amino‐5, 6, 7, 8–4H‐thiazolo‐5,4‐d‐azepine), inhibited the evoked overflow, whereas the α 1 ‐adrenoceptor agonist, methoxamine, was ineffective. The α 2 ‐adrenoceptor antagonist, rauwolscine, facilitated the evoked tritium overflow. It is concluded that the stimulation‐evoked release of noradrenaline from the sympathetic nerve fibres of the human corpus cavernosum is modulated via presynaptic α 2 ‐adrenoceptors.