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RENIN INHIBITION: IMMUNOLOGICAL PROCEDURES AND RENIN INHIBITOR PEPTIDES
Author(s) -
CORVOL P.,
MENARD J.
Publication year - 1989
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1989.tb00676.x
Subject(s) - renin inhibitor , renin–angiotensin system , pharmacology , ace inhibitor , medicine , enzyme inhibitor , endocrinology , chemistry , angiotensin converting enzyme , biochemistry , enzyme , blood pressure
Summary— Renin inhibitors represent an alternative to angiotensin‐converting enzyme inhibitors (ACEI) for the treatment of hypertension. They inhibit the renin‐angiotensin system at its first and rate limiting step, the renin‐angiotensinogen reaction. Passive administration of angiotensinogen or renin antibodies lowers blood pressure in primates to the same extent as ACEI. Chronic active immunization against renin decreases blood pressure markedly in normotensive marmosets. Renin can be inhibited by peptides derived from its prosegment. The design of compounds based on pepstatin and on angiotensinogen sequence has led to very potent and specific human renin inhibitors. Such inhibitors are active by the IV route in primates but still lack of good oral activity.