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COMPARATIVE EVALUATION OF SCAVENGER PROPERTIES OF EXIFONE, PIRACETAM AND VINBURNINE
Author(s) -
BENTUEFERRER D.,
PHILOUZE V.,
PAPE D.,
REYMANN J.M.,
ALLAIN H.,
DRIESSCHE J.
Publication year - 1989
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1989.tb00673.x
Subject(s) - piracetam , alloxan , scavenger , chemistry , free radical scavenger , radical , catechin , toxicity , pharmacology , antioxidant , polyphenol , peg ratio , diabetes mellitus , biochemistry , endocrinology , medicine , organic chemistry , finance , economics
Summary— The involvement of radical reactions in the ageing process, physiological as well as pathological, is well demonstrated. It is accepted that alloxan cyto‐toxicity is linked to a production of hydroxylated free radicals and that a substance preventing the development of alloxanic diabetes possesses scavenger properties. The objective of this work was to demonstrate, in this model, the anti‐radical effect of 3 molecules recommended in the treatment of cerebral insufficiency and a reference substance (+)‐catechin. We observed a protective action with catechin ( P <0.05) at the highest dose (100 mg/kg). PEG alone was moderately active but comparison of PEG‐alloxan and PEG‐exifone‐alloxan showed a highly significant difference ( P <0.001) at the two highest doses (60 and 120 mg/kg). Piracetam (200 and 400 mg/kg) and vinburnine (7.5 and 15 mg/kg) were inactive. Under these experimental conditions, exifone demonstrated remarkable anti‐radical properties.