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MATURATION OF AFMU EXCRETION IN INFANTS
Author(s) -
PONS G.,
REY E.,
CARRIER O.,
RICHARD M.O.,
MORAN C.,
BADOUAL J.,
OLIVE G.
Publication year - 1989
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1989.tb00461.x
Subject(s) - excretion , endocrinology , medicine , chemistry , physiology
Summary— The maturation of the N ‐acetyltransferase‐dependent AFMU production from caffeine was studied during infancy. The group of children ( N = 14) consisted of 4 premature newborn infants and ten 1–19 month‐old infants who received caffeine citrate solution for the treatment and prevention of apnea. Caffeine, AFMU, 1X and 9 other metabolites were measured in urine using HPLC. The AFMU/1X ratio did not vary significantly in this population with increasing age. In one of the infants serially studied, the AFMU/1X ratio increased dramatically between 6 and 12 months of age. This observation suggests that the maturation of N ‐acetyltransferase activity is not completed before 1 year of age implying that acetylator status cannot reliably be determined before that age. Patients studied before 1 year of age whose AFMU/1X ratio was below 0.4 may be either true slow acetylators or still immature fast acetylators.