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INTERACTION BETWEEN MOCLOBEMIDE AND ORAL TYRAMINE IN DEPRESSED PATIENTS
Author(s) -
BURGESS C.D.,
MELLSOP G.W.
Publication year - 1989
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1989.tb00029.x
Subject(s) - moclobemide , tyramine , monoamine oxidase , monoamine oxidase a , pharmacology , monoamine oxidase inhibitor , medicine , pressor response , chemistry , blood pressure , endocrinology , heart rate , biochemistry , enzyme , hippocampus , antidepressant
Summary— We investigated the pressor response to oral tyramine before and during treatment with moclobemide, a selective monoamine oxidase‐A inhibitor, in 10 depressed patients. Before moclobemide therapy, tyramine was associated with a mean (SD) maximum rise in systolic blood pressure of 4.0 (5.2) mmHg, whereas during moclobemide treatment, tyramine was associated with an increase of 24.9 (14.2) mmHg. Only one subject failed to demonstrate an increased pressor response while taking moclobemide. Moclomebide potentiates the pressor response to oral tyramine, but is safer than older nonselective monoamine oxidase inhibitors.