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HEMODYNAMIC, RENAL, AND ENDOCRINE EFFECTS OF 4‐ H INFUSIONS OF HUMAN ATRIAL NATRIURETIC PEPTIDE IN NORMAL VOLUNTEERS
Author(s) -
BIDIVILLE J.,
WAEBER G.,
PORCHET M.,
NUSSBERGER J.,
BIOLLAZ J.,
GOMEZ H.,
CALLAHAN L.,
WAEBER B.,
BRUNNER H.R.
Publication year - 1988
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1988.tb01007.x
Subject(s) - atrial natriuretic peptide , endocrinology , medicine , natriuresis , plasma renin activity , renal blood flow , aldosterone , renal function , heart rate , blood pressure , excretion , chemistry , renin–angiotensin system , renal physiology , hemodynamics
Summary— A synthetic human atrial natriuretic peptide of 26 aminoacids [human (3–28)ANP or hANP] was infused into normal male volunteers. Six subjects were infused for 4 h at 1‐wk intervals with either hANP at the rate of 0.5 or 1.0 μg/min or its vehicle in a single‐blind randomized order. Human (3–28)ANP at the dose of 0.5 μg/min raised immunoreactive plasma ANP levels from 104 ± 17 to 221 ± 24 pg/ml (mean ± SEM), but it induced no significant change in blood pressure, heart rate, effective renal plasma flow, glomerular filtration rate, or renal electrolyte excretion. At the rate of 1.0 μg/min, human (3–28)ANP increased immunoreactive plasma ANP levels from 89 ± 12 to 454 ± 30 pg/ml. It reduced effective renal plasma flow from 523 ± 40 to 453 ± 38 ml/min ( P <0.05 vs. vehicle), but left glomerular filtration rate unchanged. Natriuresis rose from 207±52 to 501±69 μmol/min ( P <0.05 vs. vehicle) and urinary magnesium excretion from 3.6±0.5 to 5.6±0.5 μmol/min ( P <0.01 vs. vehicle). The excretion rate of the other electrolytes, blood pressure, and heart rate were not significantly modified. At both doses, human (3–28)ANP tended to suppress the activity of the renin‐angiotensin‐aldosterone system. In 3 additional volunteers, the skin blood flow response to human (3–28)ANP, infused for 4 h at the rate of 1.0μg/min, was studied by means of a laser‐doppler flowmeter. The skin blood flow rose during the first 2 h of pep‐tide administration, then fell progressively to values below baseline. After the infusion was discontinued, it remained depressed for more than 2 h. Thus, in normal volunteers, human (3–28)ANP at the dose of 1.0 μg/min produced results similar to those obtained previously with rat (3–28)ANP. It enhanced natriuresis without changing the glomerular filtration rate while effective renal plasma flow fell. It also induced a transient vasodilation of the skin vascular bed.