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PLASMA KININ‐PRECURSOR LEVELS IN CLINICAL INTESTINAL INFLAMMATION
Author(s) -
SHARMA J.N.,
ZEITLIN I.J.,
MACKENZIE J.F.,
RUSSELL R.I.
Publication year - 1988
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1988.tb01005.x
Subject(s) - kininogen , kinin , medicine , inflammation , endocrinology , plasma levels , venous blood , chemistry , gastroenterology , immunology , bradykinin , receptor
Summary— Plasma kinin‐precursor (kininogen) concentrations were measured in the peripheral venous blood of 7 untreated patients with inflammatory bowel diseases, 12 healthy subjects, and 5 uncomplicated fracture cases. The mean plasma kininogen levels were significantly raised ( P <0.025) in patients with intestinal inflammation (7.0± 1.0 μg BK Eq/ml), as compared with the value found in healthy subjects (5.7 ± 0.7 fig BK Eq/ml), and in fracture cases (5.0 ± 1.2 μg BK Eq/ml). The packed cell volume did not differ ( P >0.05) between patients and control groups. Thus, the raised plasma kininogen levels observed in patients were not the result of nonspecific changes in plasma volume. It is suggested that raised plasma kininogen might be due to increased synthesis to provide substrate for excessive kinin‐formation, to a potent inflammatory agent, or to high synthesis of acute‐phase reactants. The possible significance of this observation is discussed.