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EFFECTS OF PROMETHAZINE ON ISCHEMIC AND REPERFUSION ARRHYTHMIAS IN RAT HEART
Author(s) -
ROCHETTE L.,
YAOKOUAME J.,
BRALET J.,
OPIE L.H.
Publication year - 1988
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1988.tb01004.x
Subject(s) - promethazine , mepyramine , cimetidine , ranitidine , anesthesia , medicine , pharmacology , propranolol , histamine , cardiology , antagonist , receptor
Summary— The effects of the H 1 ‐receptor antagonists promethazine, mepyramine, and chlorpheniramine on ischemic and reperfusion arrhythmias were studied in the isolated perfused rat heart. Promethazine reduced both ischemic and reperfusion arrhythmias (2times 10 ‐6 M‐7.5times 10 ‐6 M). Mepyramine and chlorpheniramine decreased these arrhythmias but at concentrations about 10 times higher. The H 2 ‐blockers cimetidine and ranitidine had no antiarrhythmic effect. Promethazine also: ( i ) increased release of noradrenaline by the heart; and ( ii ) increased coronary flow in the reperfusion period and in some mildly ischemic zones. It is proposed that promethazine exerts most of its antiarrhythmic effects by a nonspecific mechanism, possibly membrane stabilization; in addition, enhanced coronary flow may play a role.