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IMMUNOTOXICOLOGY: PROBLEMS AND CHALLENGES
Author(s) -
SPREAFICO F.
Publication year - 1988
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1988.tb00666.x
Subject(s) - immunotoxicology , current (fluid) , immune system , medicine , immunology , engineering , electrical engineering
Summary— After the definition of immunotoxicology and of the main current domains of this recently recognized, multifaceted discipline, this article examines the health significance of xenobiotically induced immune abnormalities and considers the possible mechanisms through which damage to the immune system can occur. In the second part of this review, the current status of knowledge and the problems still open with regard to preclinical testing for nonallergic immunotoxicities are examined, and current views on the general strategy for such testing discussed.