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ARE THERE CIRCADIAN AND CIRCANNUAL VARIATIONS IN ACUTE TOXICITY OF PHENOBARBITAL IN MICE?
Author(s) -
BRUGUEROLLE B.,
PRAT M.,
DOUYLLIEZ C.,
DORFMAN P.
Publication year - 1988
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1988.tb00642.x
Subject(s) - phenobarbital , circadian rhythm , toxicity , circannual rhythm , medicine , endocrinology , biology , toxicology , pharmacology , physiology
Summary— The present work aims to document the possible influence of the time of the year on the circadian pattern of phenobarbital acute toxicity in mice by determination of phenobarbital acute toxicity at four different months of the year ( i.e. October, January, April, and July). Our data indicate an important variation of phenobarbital acute toxicity throughout the year, with the maximum mortality occuring in January ( i.e. minimum LD 50 ) the minimum in July ( i.e. maximum LD 50 ). Thus, the season, not often taken into account, is an important determinant in toxicological studies.