Premium
BETA‐BLOCKING ACTIONS OF BETAXOLOL ON THE ISOLATED RAT PORTAL VEIN
Author(s) -
VIDALBERETERVIDE K.
Publication year - 1988
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1988.tb00639.x
Subject(s) - betaxolol , antagonist , portal vein , population , medicine , endocrinology , vein , timolol , receptor , surgery , intraocular pressure , environmental health
Summary— The characteristics of the β‐adrenoceptor population mediating the actions of noradrenaline and isoproterenol in the rat portal vein were examined in comparison with those in the rat atria. In the portal vein, the pA 2 values obtained for the selective β 1 ‐adrenoceptor antagonist betaxolol were 100‐fold lower than those obtained in the atria, suggesting that in the rat portal vein a population of β 2 ‐adrenoceptors is highly predominant.