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ACUTE RELEASE OF CATECHOLAMINES ON CIRCULATING BLOOD CELL ADRENOCEPTORS AND METABOLIC INDICES IN DOG
Author(s) -
VALET P.,
DAMASEMICHEL C.,
TAOUIS M.,
MONTASTRUC J.L.,
COTONAT J.,
MONTASTRUC P.
Publication year - 1988
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1988.tb00638.x
Subject(s) - medicine , endocrinology , catecholamine , endogeny , platelet , adrenergic receptor , chemistry , denervation , beta (programming language) , alpha (finance) , epinephrine , receptor , computer science , programming language , construct validity , nursing , patient satisfaction
Summary— The effects of acute release of endogenous catecholamines on both platelet alpha 2 and leukocyte beta adrenoreceptors and metabolic indices (glucose and free fatty acids) were investigated in dogs by means of a model of neurogenic hypertension following acute sinoaortic denervation (ASAD). Despite the marked increase in catecholamine levels (+4.2‐fold for noradrenaline and 16.7‐fold for adrenaline, for example, at minute 45 following ASAD) and in glucose plasma levels, and the significant decrease in free fatty acid plasma levels, no change in platelet alpha 2 or leukocyte beta adrenoreceptor binding sites (number as well as affinity) was observed during the whole experiment. It is suggested that the number of platelet alpha 2 ‐ and leukocyte beta‐adrenoreceptors is not submitted to short‐term regulation, at least by endogenous catecholamines in dogs.