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EFFECTS OF ORAL PRAZOSIN ON TOTAL PLASMA DIGOXIN LEVELS
Author(s) -
ÇOPUR S.,
TOKGÖZOĜLU L.,
OTO A.,
ORAM E.,
UĜURLU Ş.
Publication year - 1988
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1988.tb00616.x
Subject(s) - prazosin , digoxin , discontinuation , medicine , plasma concentration , endocrinology , pharmacology , heart failure , antagonist , receptor
Summary— Prazosin and digoxin are frequently coadministered in clinical practice. To determine the effects of oral prazosin treatment on steady‐state digoxin levels, 20 patients receiving a constant maintenance dose of digoxin, who had normal renal and liver functions and were not receiving any other treatment, were given 5 mg of prazosin for 3 days. Plasma digoxin levels were measured before, on days 1 and 3 of prazosin treatment, and after prazosin had been discontinued. It was found that prazosin significantly increased plasma digoxin levels. On discontinuation of prazosin digoxin levels returned to their previous values.