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THE EFFECTS OF AGEING ON AMINOPYRINE AND CAFFEINE BREATH TESTS IN THE RAT
Author(s) -
FEELY J.,
KELLEHER P.,
ODUMOSU A.
Publication year - 1987
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1987.tb00574.x
Subject(s) - ageing , caffeine , demethylation , breath test , medicine , endocrinology , in vivo , chemistry , biology , biochemistry , gene expression , microbiology and biotechnology , dna methylation , gene , helicobacter pylori
Summary— The influence of ageing on demethylation of 14 C‐aminopyrine (AP) and 14 C‐caffeine (Caf) in Wistar littermate rats was studied serially using the 14 CO 2 ‐breath test. In both sexes, the elimination half‐life ( t 1/2) of 14 C‐AP fell from a mean of approximately 75 min when weaned at 17 days to 45 min at maturity (49 days); thereafter t 1/2 became prolonged, being most prolonged (82 min) in elderly male rats (210 days). Similarly, t 1/2 of 14 C‐Caf was also prolonged with ageing. These studies using in vivo and longitudinal techniques indicate the importance of ageing on hepatic demethylation.