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PHARMACOKINETICS OF HIGH‐DOSE IV ALIZAPRIDE IN PREVENTION OF CISPLATIN‐INDUCED EMESIS
Author(s) -
CANAL P.,
ROCHE H.,
PASQUIER M.,
BUGAT R.,
BERG D.,
SOULA G.,
CARTON M.
Publication year - 1987
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1987.tb00559.x
Subject(s) - pharmacokinetics , antiemetic , medicine , pharmacology , anesthesia , drug , vomiting
Summary— Alizapride is a new antidopaminergic‐related benzamide with specific antiemetic properties. Pharmacokinetics at a high repetitive dose (16 mg/kg) shows a biexponential plasma decay with T 1/2α of 8.33 ± 2.47 min and T 1/2β 2.8 ± 0.7 hr. Large Vdss and high total body clearance are apparent. We demonstrate an increase in drug exposure during the first 6 hr after CDDP infusion by shortening the interval between injections. We conclude that the rate of infusion of alizapride could be important in the efficacy of the drug.