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EFFECT OF PEPTIDYL‐DIPEPTIDASE INHIBITORS IN EXPERIMENTAL CONVULSIONS IN MICE
Author(s) -
MIÑANO F.J.,
SERRANO J.S.,
SANCIBRIÁN M.,
SERRANO M.I.
Publication year - 1987
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1987.tb00547.x
Subject(s) - captopril , bicuculline , anticonvulsant , strychnine , enalapril , pharmacology , chemistry , epilepsy , convulsion , gaba receptor antagonist , endocrinology , medicine , antagonist , receptor , angiotensin converting enzyme , blood pressure , psychiatry
Summary— The anticonvulsant effect of compounds that inhibit peptidyl‐dipeptidase (PDP) on bicuculline (BIC)‐ and strychnine (STRYC)‐induced seizures was assessed after intracerebroventricular (ICV) or intraperitoneal (IP) administration in Swiss albino mice. STRYC‐induced seizures were delayed by ICV injections and high IP doses of captopril, but not by ICV or IP injections of enalapril or by lower doses of captopril (0.1 mg/kg and 1 mg/kg IP). BIC‐induced seizures were not suppressed by ICV or IP injections of either compound; on the contrary, captopril and enalapril exhibited proconvulsant effects when given IP or ICV by shortening the time of onset of tonic seizures and death. Results indicate that the anticonvulsant effect of captopril against STRYC‐induced seizures is not mediated by central γ‐aminobutyric acid (GABA) receptors or by the inhibition of PDP.