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EFFECT OF CLONIDINE ON ADRENAL MEDULLA CATECHOLAMINE LEVELS IN RATS
Author(s) -
GAILLARD G.,
TRAN M.A.,
ROSTIN M.,
SALVAYRE R.,
MONTASTRUC J.L.
Publication year - 1987
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/j.1472-8206.1987.tb00540.x
Subject(s) - clonidine , adrenal medulla , catecholamine , endocrinology , medicine , medulla
Summary— The effects of clonidine on adrenal medulla catecholamines levels were studied in normotensive rats. Intraperitoneal injections (50, 100 μ/kg) of clonidine caused a dose‐dependent decrease in adrenaline content of the gland. This effect was suppressed by denervation of the adrenal medulla, i.e. unilateral section of splanchnic fibers performed 5 days before. These results demonstrate that clonidine decreases the catecholamine content of the adrenal medulla only through a central action. They suggest that the adrenal medulla is involved in the hypotensive effect of clonidine.