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Administration of Lactobacillus fermentum CRL1446 increases intestinal feruloyl esterase activity in mice
Author(s) -
Abeijón Mukdsi M.C.,
Gauffin Cano M.P.,
González S.N.,
Medina R.B.
Publication year - 2012
Publication title -
letters in applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.698
H-Index - 110
eISSN - 1472-765X
pISSN - 0266-8254
DOI - 10.1111/j.1472-765x.2011.03166.x
Subject(s) - lactobacillus fermentum , tbars , ferulic acid , oral administration , lactobacillus , thiobarbituric acid , lipid peroxidation , bioavailability , lactic acid , pediococcus acidilactici , biology , glutathione reductase , chemistry , antioxidant , food science , endocrinology , medicine , biochemistry , pharmacology , glutathione peroxidase , superoxide dismutase , bacteria , genetics , fermentation , lactobacillus plantarum
Aims: To evaluate the effect of oral administration of Lactobacillus fermentum CRL1446 on the intestinal feruloyl esterase (FE) activity and oxidative status of mice. Methods and Results: Adult Swiss albino mice received Lact. fermentum CRL1446 at the doses 10 7 and 10 9 cells per day per mouse for 2, 5, 7 and 10 days. Intestinal FE activity, intestinal microbiota counts, plasmatic thiobarbituric acid‐reactive substances (TBARS) percentage and glutathione reductase (GR) activity were determined. Mice that received Lact. fermentum CRL1446 at the dose 10 7 cells per day for 7 days showed a twofold increase in total intestinal FE activity, compared to the nontreated group. In large intestine content, FE activity increased up to 6·4 times. No major quantitative changes in colonic microbiota were observed in treated animals. Administration of this strain produced an approx. 30–40% decrease in the basal levels of plasmatic TBARS and an approx. twofold increase in GR activity from day 5 of feeding with both doses. Conclusions: Oral administration of Lact. fermentum CRL1446 to mice increases total intestinal FE activity, decreases the basal percentage of plasmatic lipoperoxides and increases GR activity. Significance and Impact of the Study: Lactobacillus fermentum CRL1446 could be orally administered as a dietary supplement or functional food for increasing the intestinal FE activity to enhance the bioavailability of ferulic acid, thus improving oxidative status.