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Triclosan – an update
Author(s) -
Saleh S.,
Haddadin R.N.S.,
Baillie S.,
Collier P.J.
Publication year - 2011
Publication title -
letters in applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.698
H-Index - 110
eISSN - 1472-765X
pISSN - 0266-8254
DOI - 10.1111/j.1472-765x.2010.02976.x
Subject(s) - triclosan , mode of action , microbiology and biotechnology , reductase , action (physics) , chemistry , biology , biochemistry , enzyme , medicine , physics , pathology , quantum mechanics
The discovery in 1998 that triclosan has a site‐specific action in the bacterial cell as an inhibitor of NADH‐ or NADPH‐dependent enoyl‐acyl carrier protein reductase led to a lively debate in the scientific press. The thesis of this debate was that such a mode of action may allow triclosan to induce resistance and cross‐resistance in bacterial cells. The debate last saw review in 2004, and this paper aims at updating our knowledge in this area, given recent research on the topic.