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Vapour‐phase hydrogen peroxide inactivates Yersinia pestis dried on polymers, steel, and glass surfaces
Author(s) -
Rogers J.V.,
Richter W.R.,
Shaw M.Q.,
Choi Y.W.
Publication year - 2008
Publication title -
letters in applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.698
H-Index - 110
eISSN - 1472-765X
pISSN - 0266-8254
DOI - 10.1111/j.1472-765x.2008.02421.x
Subject(s) - hydrogen peroxide , yersinia pestis , human decontamination , virulence , peroxide , chemistry , microbiology and biotechnology , nuclear chemistry , biology , organic chemistry , medicine , biochemistry , pathology , gene
Aims: This study evaluated the inactivation of virulent Yersinia pestis dried on polymers, steel, and glass surfaces using vapour‐phase hydrogen peroxide. Methods and Results: A suspension of Y. pestis CO92 (1·70 × 10 8 CFU) was dried on 10 different types of test surfaces and exposed to vapour‐phase hydrogen peroxide fumigation for a contact time of 2 h. A significant reduction in the log 10 CFU of Y. pestis on all 10 materials was observed between the controls evaluated after a 1 h drying time and unexposed controls evaluated after the decontamination run. Qualitative growth assessment showed that vapour‐phase hydrogen peroxide exposure inactivated Y. pestis on all replicates of the 10 test materials as well as biological indicators up to 7 days postexposure. Conclusions: Virulent Y. pestis CO92 is inactivated on polymers, steel, and glass surfaces when exposed to vapour‐phase hydrogen peroxide without observable physical damage to the test materials. Significance and Impact of the Study: This study provides information for using vapour‐phase hydrogen peroxide as a practical process for the decontamination of virulent Y. pestis in circumstances where time‐dependent attenuation/inactivation or liquid/heat decontamination may not be the most suitable approach.