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Sensitivity of Escherichia coli to proline analogues during osmotic stress and anaerobiosis
Author(s) -
Reese L.M.,
Cutler K.O.,
Deutch C.E.
Publication year - 1996
Publication title -
letters in applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.698
H-Index - 110
eISSN - 1472-765X
pISSN - 0266-8254
DOI - 10.1111/j.1472-765x.1996.tb01143.x
Subject(s) - las vegas , escherichia coli , library science , chemistry , computer science , law , political science , biochemistry , gene , tourism
L.M. REESE, K.O. CUTLER AND C.E. DEUTCH. 1996. The sensitivity of wild‐type Escherichia coli K‐12 to a series of proline analogues was determined in cultures containing increasing concentrations of NaCl under both aerobic and anaerobic conditions. The bacteria were most sensitive to L‐azetidine‐2–carboxylate and L‐thiazolidine‐4–carboxylate. The minimum inhibitory concentrations for these compounds decreased progressively during osmotic stress, but the bacteria were much more sensitive to these proline analogues under aerobic conditions than during anaerobiosis. The reduced sensitivity under anaerobic conditions did not reflect degradation of the compounds in the culture medium. Since both urine and medullary renal tissue contain relatively low oxygen concentrations, these results raise doubts about the potential use of proline or glycine betaine analogues in treating urinary tract infections.